The agri-food industry generates around 50% of global waste. Of this waste, only 36% is recycled, although the potential recovery could be as high as 60%. The EU-funded MODEL2BIO project aims to develop a decision-support system tool to determine the agri-food industry’s residual streams composition and to formulate recommendations on how to use them more efficiently. The tool will be based on the interconnection of a simulation module, an optimisation algorithm and a life cycle analysis module. The project’s recommendations will be formulated under a holistic perspective (technical, economic, environmental and social).